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  • FAQ: What kind of RNA can be methylated using the mRNA Cap 2'-O-Methyltransferase?

    mRNA Cap 2'-O-Methyltransferase requires capped RNA as substrate. Capped RNA can be prepared via in-vitro transcription (T7 High Yield RNA Synthesis Kit, NEB# E2040 ) using cap analog or by enzymatic capping using the Vaccinia capping enzyme (NEB# M2080 ).