FAQ: How well does Endonuclease V cleave at U:A sites?

Endonuclease V does not work well at U:A sites. However, it will cleave the phosphodiester bond 3' to a deoxyuridine mismatch if it is a U:G mismatch. For additional information please refer to the "DNA Repair Glycosylases on Various Damages Bases" page in our website.