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  • FAQ: Can dsDNA Fragmentase be used with GC-rich or AT-rich DNA?

    Yes. The incubation times for GC-rich and AT-rich DNA are slightly different and these are described in the dsDNA Fragmentase protocols on the NEB website. Sequencing of GC-rich and AT-rich DNA prepared using dsDNA Fragmentase or Covaris shearing was found to be equivalent.