FAQ: Are samples stored in DNA/RNA Protection Reagent compatible with the new version of the kit (Monarch Spin RNA Isolation Kit (Mini), NEB #T2110)?

Yes, samples preserved DNA/RNA Protection Reagent can be processed with the Monarch Spin RNA Isolation Kit (Mini). We recommend proceeding with mechanical homogenization and/or Proteinase K in the DNA/RNA Protection Reagent as recommended in Monarch® Total RNA Miniprep Kit (NEB #T2010) protocol, and replacing RNA Lysis Buffer addition with Monarch StabiLyse DNA/RNA Buffer to continue with the new kit's protocol.