Role of Carbohydrates in the Inflammation Response

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One example of the role of carbohydrates in cell recognition

During inflammation, circulating leukocytes are recruited via their glycans, which are recognized by specific receptors (selectins) in the endothelial wall. The leukocytes stop and firmly adhere to the endothelium before moving out towards the injured tissue. This process is a critical component of the innate immune response: patients affected with glycosylation disorders often present with recurrent infections, due to leukocyte adhesion deficiency.