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Epigenetics

Epigenetics is the study of heritable changes in gene expression that are not encoded in the DNA of the genome. Encouraging evidence has linked epigenetic effects to oncogenesis, progression and treatment of cancer (1), the regulation of development and function of the nervous system (2), gene regulation (3), cellular stress events (3), nutrigenomics (4), aging and DNA repair (5). Considerable ongoing efforts are directed towards identifying the dynamic functions of various modifications to DNA and its associated proteins and elucidating their mechanisms.

  1. Baylin, S. and Jones, P. (2011) Nature Rev Cancer (10), 726-734. PMID: 21941284 
  2. Riccio, A., (2010) Nature Neuroscience, 13, 1330-1337. PMID: 20975757 
  3. Huang, J. et al. (2006) Nature, 444, 629-632. PMID: 17108971 
  4. Park, L.K., Friso, S. and Choi, S.W. (2011) Proc. Nutr. Soc. Nov 4, 1-9. 
  5. Pahlich, S., Zakaryan, R.P. and Gehring., H. (2006) Biochim, Biophys. Acta. 1764, 1890-1903. PMID: 17010682

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Epigenetics includes these areas of focus:

Control DNA for Epigenetics
Restriction Enzymes for Epigenetics
DNA Methylation Analysis
5-hmC Detection & Analysis
Methylated DNA Analysis
Bisulfite Conversion
Histones & Nucleosome Assembly
DNA Enrichment
Antibodies
ChIP

FAQs for Epigenetics

    Publications related to Epigenetics

  1. Mooijman D, Dey S S, Boisset JC, Crosetto N, van Oudenaarden A 2016. Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction Nature Biotechnology. 34, PubMedID: 27347753, DOI: 10.1038/nbt.3598
  2. Marx V. 2016. Genetics: profiling DNA methylation and beyond Nature Methods. 13, PubMedID: , DOI: 10.1038/nmeth.3736
  3. Estève P., Zhang G., Ponnaluri V., Kanneganti 2015. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates Nucleic Acids Res. , PubMedID: 26553800, DOI: 10.1093/nar/gkv1162
  4. Page A., Paoli P., Salvador E., White S., French J., Mann J. 2015. Hepatic Stellate Cell Transdifferentiation Involves Genome-Wide Remodeling of the DNA Methylation Landscape J Hepatol. , PubMedID: 26632634, DOI: 10.1016/j.jhep.2015.11.024
  5. Kienhöfer S., Musheev M., Stapf U., Helm M., Schomacher L., Niehrs C., Schäfer A. 2015. GADD45a physically and functionally interacts with TET1Publication Differentiation. , PubMedID: 26546041, DOI: 10.1016/j.diff.2015.10.003
  6. Chernov AV., Reyes L., Peterson S., Strongin AY. 2015. Depletion of CG-Specific Methylation in Mycoplasma hyorhinis Genomic DNA after Host Cell Invasion PLoS One. 10, PubMedID: 26544880, DOI: 10.1371/journal.pone.0142529
  7. Wee E., Ngo T., Trau M. 2015. A simple bridging flocculation assay for rapid, sensitive and stringent detection of gene specific DNA methylation Sci Rep. 5, PubMedID: 26458746, DOI: 10.1038/srep15028
  8. Chandra S, Baribault C, Lacey M, Ehrlich M 2014. Myogenic differential methylation: diverse associations with chromatin structure Biology (Basel). 3(2), PubMedID: 24949935, DOI: 10.3390/biology3020426
  9. Hughes J.R., Roberts N., McGowan S., Hay D., Giannoulatou E., Lynch M., De Gobbi M., Taylor S., Gibbons R., Higgs D.R. 2014. Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment Nat Genet. 46 (2), PubMedID: 24413732, DOI: doi:10.1038/ng.2871
  10. Sexton T, Kurukuti S, Mitchell JA, Umlauf D, Nagano T, Fraser P 2012. Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip Nat Protoc. 7(7), PubMedID: 22722369, DOI: 10.1038/nprot.2012.071
  11. Wolff, E.M. et al. 2011. Hypomethylation of a LINE-1 Promoter Activates an Alternate Transcript of the MET Oncogene in Bladders with Cancer PLoS Genet. . 6, PubMedID: 20421991, DOI:
  12. Lieberman-Aiden E., van Berkum N., Williams L., Imakaev M., Ragoczy T., Telling A., Amit I., Lajoie B., Sabo P., Dorschner M., Sandstrom R., Bernstein B., BenderM. A., Groudine M., Gnirke A., Stamatoyannopoulos J., Mirny L., Lander E., Dekker J. 2009. Comprehensive mapping of long range interactions reveals folding principles of the human genome Science. Oct 9; 326(5950) , PubMedID: , DOI: