DNA Modification

New England Biolabs offers a wide range of reagents that facilitate DNA modification or repair for downstream cloning, amplification, labeling or sequencing applications. We also offer modifying enzymes that can be used to study the effect of DNA methylation on genetic expression.

DNA Modification

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Order EnGen® sgRNA Synthesis Kit, S. pyogenes

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Order Nuclease-free Water

DNA Nicking

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Order APE 1

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Order CutSmart® Buffer

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Order Diluent A

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Order Diluent B

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Order Endonuclease IV

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Order Endonuclease V

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Order Endonuclease VIII

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Order Fpg

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Order Lambda DNA (N6-methyladenine-free)

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Order Nb.BbvCI

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Order Nb.BsmI

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Order Nb.BssSI

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Order Nb.BtsI

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Order NEBuffer™ 1

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Order NEBuffer™ 1.1

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Order NEBuffer™ 2

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Order NEBuffer™ 2.1

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Order NEBuffer™ 3

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Order NEBuffer™ 3.1

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Order NEBuffer™ 4

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Order NEBuffer™ EcoRI

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Order NEBuffer™ Set (1.1, 2.1, 3.1 and CutSmart®)

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Order Nt.AlwI

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Order Nt.BbvCI

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Order Nt.BsmAI

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Order Nt.BspQI

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Order Nt.BstNBI

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Order SspI

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Order T4 PDG (T4 Endonuclease V)

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Order T7 Endonuclease I

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Order Thermolabile USER® II Enzyme

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Order Tma Endonuclease III

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Order Tth Endonuclease IV

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Order USER® Enzyme

DNA End Modification

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Order Deoxynucleotide (dNTP) Solution Mix

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Order Deoxynucleotide (dNTP) Solution Set

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Order Exonuclease I Reaction Buffer

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Order Exonuclease T

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Order NEBNext® End Repair Module

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Order RecJf

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Order T4 Polynucleotide Kinase

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Order Alkaline Phosphatase, Calf Intestinal (CIP)

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Order Amylose Magnetic Beads

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Order DNA Polymerase I, Large (Klenow) Fragment

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Order FspI

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Order HpaI

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Order Lambda DNA

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Order Lambda DNA (N6-methyladenine-free)

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Order M13mp18 RF I DNA

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Order Mung Bean Nuclease

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Order Phusion® High-Fidelity DNA Polymerase

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Order Phusion® High-Fidelity PCR Master Mix with GC Buffer

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Order Phusion® High-Fidelity PCR Master Mix with HF Buffer

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Order PsiI

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Order Quick Blunting™ and Quick Ligation™ Kits

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Order Quick Blunting™ Kit

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Order T4 DNA Polymerase

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Order Quick Blunting™ and Quick Ligation™ Kits

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Order Quick Blunting™ Kit

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Order Quick Dephosphorylation Kit

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Order T4 DNA Ligase Reaction Buffer

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Order T4 Polynucleotide Kinase (3' phosphatase minus)

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Order Alkaline Phosphatase, Calf Intestinal (CIP)

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Order Antarctic Phosphatase

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Order Antarctic Phosphatase Reaction Buffer

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Order Lambda DNA

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Order Lambda DNA (N6-methyladenine-free)

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Order M13mp18 RF I DNA

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Order p-Nitrophenyl Phosphate (PNPP)

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Order Quick Dephosphorylation Kit

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Order Shrimp Alkaline Phosphatase (rSAP)

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Order T4 Polynucleotide Kinase Reaction Buffer

DNA Repair

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Order 5-methyl-dCTP

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Order Afu Uracil-DNA Glycosylase (UDG)

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Order Antarctic Thermolabile UDG

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Order APE 1

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Order Deoxynucleotide (dNTP) Solution Mix

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Order Deoxynucleotide (dNTP) Solution Set

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Order Endonuclease III (Nth)

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Order Endonuclease IV

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Order Endonuclease V

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Order Endonuclease VIII

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Order Fpg

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Order hAAG

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Order hSMUG1

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Order PreCR® Repair Mix

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Order RecA

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Order RecAf

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Order Sulfolobus DNA Polymerase IV

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Order T4 PDG (T4 Endonuclease V)

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Order T7 Endonuclease I

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Order Thermolabile USER® II Enzyme

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Order Thermostable FEN1

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Order Tma Endonuclease III

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Order Tth Endonuclease IV

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Order Uracil Glycosylase Inhibitor (UGI)

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Order Uracil-DNA Glycosylase (UDG)

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Order USER® Enzyme

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Order β-Nicotinamide adenine dinucleotide (NAD+)

DNA & Protein Methylation

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Order AluI Methyltransferase

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Order BamHI Methyltransferase

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Order CpG Methyltransferase (M.SssI)

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Order dam Methyltransferase

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Order EcoGII Methyltransferase

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Order EcoRI Methyltransferase

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Order EpiMark® Nucleosome Assembly Kit

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Order GpC Methyltransferase (M.CviPI)

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Order Haelll Methyltransferase

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Order Hhal Methyltransferase

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Order Histone H10 Human, Recombinant

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Order Histone H2A Human, Recombinant

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Order Histone H2A/H2B Dimer Human, Recombinant

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Order Histone H2B Human, Recombinant

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Order Histone H3.1 Human, Recombinant

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Order Histone H3.1/H4 Tetramer Human, Recombinant

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Order Histone H3.2 Human, Recombinant

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Order Histone H3.3 Human, Recombinant

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Order Histone H4 Human, Recombinant

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Order HpaII Methyltransferase

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Order MspI Methyltransferase

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Order TaqI Methyltransferase

DNA Ligation

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Order 9°N™ DNA Ligase

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Order Adenosine 5'-Triphosphate (ATP)

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Order Blunt/TA Ligase Master Mix

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Order E. coli DNA Ligase

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Order Instant Sticky-end Ligase Master Mix

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Order NEB® 5-alpha Electrocompetent E. coli

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Order NEBNext® Multiplex Oligos for Illumina® (Index Primers Set 1)

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Order NEBNext® Multiplex Oligos for Illumina® (Methylated Adaptor, Index Primers Set 1)

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Order NEBNext® Quick Ligation Module

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Order NEBNext® Ultra™ Ligation Module

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Order pSV40-GLuc Control Plasmid

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Order Quick Blunting™ and Quick Ligation™ Kits

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Order Quick Blunting™ Kit

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Order T3 DNA Ligase

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Order T4 DNA Ligase

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Order T4 DNA Ligase Reaction Buffer

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Order T7 DNA Ligase

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Order Taq DNA Ligase

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Order Taq DNA Ligase Reaction Buffer

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Order Thermostable 5´ AppDNA/RNA Ligase

DNA Nicking

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Order APE 1

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Order CutSmart® Buffer

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Order Diluent A

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Order Diluent B

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Order Endonuclease IV

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Order Endonuclease V

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Order Endonuclease VIII

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Order Fpg

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Order Lambda DNA (N6-methyladenine-free)

Close

Order Nb.BbvCI

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Order Nb.BsmI

Close

Order Nb.BssSI

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Order Nb.BtsI

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Order NEBuffer™ 1

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Order NEBuffer™ 1.1

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Order NEBuffer™ 2

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Order NEBuffer™ 2.1

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Order NEBuffer™ 3

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Order NEBuffer™ 3.1

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Order NEBuffer™ 4

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Order NEBuffer™ EcoRI

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Order NEBuffer™ Set (1.1, 2.1, 3.1 and CutSmart®)

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Order Nt.AlwI

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Order Nt.BbvCI

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Order Nt.BsmAI

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Order Nt.BspQI

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Order Nt.BstNBI

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Order SspI

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Order T4 PDG (T4 Endonuclease V)

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Order T7 Endonuclease I

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Order Thermolabile USER® II Enzyme

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Order Tma Endonuclease III

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Order Tth Endonuclease IV

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Order USER® Enzyme

DNA End Modification

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Order Deoxynucleotide (dNTP) Solution Mix

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Order Deoxynucleotide (dNTP) Solution Set

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Order Exonuclease I Reaction Buffer

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Order Exonuclease T

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Order NEBNext® End Repair Module

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Order RecJf

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Order T4 Polynucleotide Kinase

DNA Blunting

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Order Alkaline Phosphatase, Calf Intestinal (CIP)

Close

Order Amylose Magnetic Beads

Close

Order DNA Polymerase I, Large (Klenow) Fragment

Close

Order FspI

Close

Order HpaI

Close

Order Lambda DNA

Close

Order Lambda DNA (N6-methyladenine-free)

Close

Order M13mp18 RF I DNA

Close

Order Mung Bean Nuclease

Close

Order Phusion® High-Fidelity DNA Polymerase

Close

Order Phusion® High-Fidelity PCR Master Mix with GC Buffer

Close

Order Phusion® High-Fidelity PCR Master Mix with HF Buffer

Close

Order PsiI

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Order Quick Blunting™ and Quick Ligation™ Kits

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Order Quick Blunting™ Kit

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Order T4 DNA Polymerase

DNA Phosphorylation

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Order Quick Blunting™ and Quick Ligation™ Kits

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Order Quick Blunting™ Kit

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Order Quick Dephosphorylation Kit

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Order T4 DNA Ligase Reaction Buffer

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Order T4 Polynucleotide Kinase (3' phosphatase minus)

DNA Dephosphorylation

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Order Alkaline Phosphatase, Calf Intestinal (CIP)

Close

Order Antarctic Phosphatase

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Order Antarctic Phosphatase Reaction Buffer

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Order Lambda DNA

Close

Order Lambda DNA (N6-methyladenine-free)

Close

Order M13mp18 RF I DNA

Close

Order p-Nitrophenyl Phosphate (PNPP)

Close

Order Quick Dephosphorylation Kit

Close

Order Shrimp Alkaline Phosphatase (rSAP)

Close

Order T4 Polynucleotide Kinase Reaction Buffer

DNA Repair

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Order 5-methyl-dCTP

Close

Order Afu Uracil-DNA Glycosylase (UDG)

Close

Order Antarctic Thermolabile UDG

Close

Order APE 1

Close

Order Deoxynucleotide (dNTP) Solution Mix

Close

Order Deoxynucleotide (dNTP) Solution Set

Close

Order Endonuclease III (Nth)

Close

Order Endonuclease IV

Close

Order Endonuclease V

Close

Order Endonuclease VIII

Close

Order Fpg

Close

Order hAAG

Close

Order hSMUG1

Close

Order PreCR® Repair Mix

Close

Order RecA

Close

Order RecAf

Close

Order Sulfolobus DNA Polymerase IV

Close

Order T4 PDG (T4 Endonuclease V)

Close

Order T7 Endonuclease I

Close

Order Thermolabile USER® II Enzyme

Close

Order Thermostable FEN1

Close

Order Tma Endonuclease III

Close

Order Tth Endonuclease IV

Close

Order Uracil Glycosylase Inhibitor (UGI)

Close

Order Uracil-DNA Glycosylase (UDG)

Close

Order USER® Enzyme

Close

Order β-Nicotinamide adenine dinucleotide (NAD+)

DNA & Protein Methylation

Close

Order AluI Methyltransferase

Close

Order BamHI Methyltransferase

Close

Order CpG Methyltransferase (M.SssI)

Close

Order dam Methyltransferase

Close

Order EcoGII Methyltransferase

Close

Order EcoRI Methyltransferase

Close

Order EpiMark® Nucleosome Assembly Kit

Close

Order GpC Methyltransferase (M.CviPI)

Close

Order Haelll Methyltransferase

Close

Order Hhal Methyltransferase

Close

Order Histone H10 Human, Recombinant

Close

Order Histone H2A Human, Recombinant

Close

Order Histone H2A/H2B Dimer Human, Recombinant

Close

Order Histone H2B Human, Recombinant

Close

Order Histone H3.1 Human, Recombinant

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Order Histone H3.1/H4 Tetramer Human, Recombinant

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Order Histone H3.2 Human, Recombinant

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Order Histone H3.3 Human, Recombinant

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Order Histone H4 Human, Recombinant

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Order HpaII Methyltransferase

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Order MspI Methyltransferase

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Order TaqI Methyltransferase

DNA Ligation

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Order 9°N™ DNA Ligase

Close

Order Adenosine 5'-Triphosphate (ATP)

Close

Order Blunt/TA Ligase Master Mix

Close

Order E. coli DNA Ligase

Close

Order Instant Sticky-end Ligase Master Mix

Close

Order NEB® 5-alpha Electrocompetent E. coli

Close

Order NEBNext® Multiplex Oligos for Illumina® (Index Primers Set 1)

Close

Order NEBNext® Multiplex Oligos for Illumina® (Methylated Adaptor, Index Primers Set 1)

Close

Order NEBNext® Quick Ligation Module

Close

Order NEBNext® Ultra™ Ligation Module

Close

Order pSV40-GLuc Control Plasmid

Close

Order Quick Blunting™ and Quick Ligation™ Kits

Close

Order Quick Blunting™ Kit

Close

Order T3 DNA Ligase

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Order T4 DNA Ligase

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Order T4 DNA Ligase Reaction Buffer

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Order T7 DNA Ligase

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Order Taq DNA Ligase

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Order Taq DNA Ligase Reaction Buffer

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Order Thermostable 5´ AppDNA/RNA Ligase