Mapping protein-protein contacts (two-hybrid alternative)

General methods

Kay, B.K. et al. (2001) "Screening phage-displayed combinatorial peptide libraries."Methods 24, 240-246.

Lunder, M. et al. (2008) "Ultrasound in phage display: a new approach to nonspecific elution." Biotechniques 44, 893-900.

Messmer, B.T. et al. (2000) "Sequential determination of ligands binding to discrete components in heterogeneous mixtures by iterative panning and blocking (IPAB)." J. Mol. Biol. 296, 821-832.

Messmer, B.T. and D.S. Thaler (2001) "Specific blocking to improve biopanning in biological samples such as serum and hybridoma supernatants." Biotechniques 30, 798-802.

Noren, K.A. and C.J. Noren (2001) "Construction of high-complexity combinatorial phage display peptide libraries." Methods 23, 169-178.

Noren, K.A. et al. (2000) "Construction and use of pIII-displayed peptide libraries." Phage Display: A Laboratory Manual. Cold Spring Harbor Laboratory Press, 19.1-19.41.

Rahim, A. et al. (2003) "High-throughput Pyrosequencing of a phage display library for the identification of enriched target-specific peptides." Biotechniques 35, 317-324.

Tarr, A. W. et al. (2005) "Tagged polymerase chain reaction subtractive hybridization for the enrichment of phage display random peptide libraries" Anal. Biochem. 339, 61-68.

top

Receptor-specific peptides (purified receptor panning)

An, P. et al. (2004) "Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library." Int J Cancer 111, 165-173.

Biorn, A.C. et al. (2004) "Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions." Biochemistry 43, 1928-1938.

Ding, Y. L. et al. (2006) [Isolation of a novel peptide that binds to BlyS from a 12-mer phage display peptide library.] Yi Chuan 28, 208-11.

Du, B. et al. (2006) "In vitro panning of a targeting peptide to hepatocarcinoma from a phage display peptide library." Biochem. Biophys. Res. Commun.342, 956-962.

Ferrer, M. and S. C. Harrison (1999) "Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries." J Virol 73, 5795-5802.

Guo, H.P. et al. (2002) "Screening of tumor necrosis factor-alpha-binding peptides by phage display peptide library." Di Yi Jun Yi Da Xue Xue Bao 22, 597-599.

Hessling, J. et al. (2003) "Peptide G protein agonists from a phage display library." Biochem Pharmacol 65, 961-7.

Hetian, L. et al. (2002) "A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular Endothelial Growth Factor to Its Kinase Domain Receptor." J Biol Chem 277, 43137-43142.

Hong, T. M. et al. (2007) "Targeting neuropilin-1 as an antitumor strategy in lung cancer' Clin. Canc. Res. 13, 4759-4768.

Howell, R. C. et al. (2007) "Phage display library derived peptides that bind to human tumor melanin as potential vehicles for targeted radionuclide therapy of metastatic melanoma." Bioconj. 18, 1739-1748.

Hsu, C.L. et al. (2003) "The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs." J Biol Chem 278, 23691-23698.

Koolpe, M. et al. (2002) "An ephrin mimetic peptide that selectively targets the EphA2 receptor." J Biol Chem 277, 46974-46979.

Kraft, S. et al. (1999) "Definition of an unexpected ligand recognition motif for alphav beta6 integrin." J Biol Chem 274, 1979-1985.

Li, Z. et al. (2005) "Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeautics." FASEB J. 19, 1978-85.

Luo, X. et al. (2002) "The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20." Mol Cell 9, 59-71.

Magdesian, M. H. et al. (2005) "Peptide Blockers of the Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Amyloid b ." J. Biol. Chem. 280, 31085-31090.

Mohrlüder, J. et al (2007) "Identification of calreticulin as a ligand of GABARAP by phage display screening of a peptide library." FEBS J. 274, 5543-5555.

Pillutla, R.C. et al. (2002) "Peptides identify the critical hotspots involved in the biological activation of the insulin receptor." J Biol Chem 277, 22590-22594.

Su, J.L. et al. (2005) "A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth" Canc. Res. 65, 4827-4835.

Tournaire, R. et al. (2004) "A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor." EMBO Rep 5, 262-267.

Wang, F.-Y. et al. (2006) "Selection of CC chemokine receptor 5-binding peptide from a phage display library." Biosci. Biotechnol. Biochem. 70, 2035-2041.

White, S. J. et al. (2005) "Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning." Peptides 26, 1264-1269.

top

Receptor-specific peptides (whole cell panning)

Binetruy-Tournaire, R. et al. (2000) "Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis." EMBO J. 19, 1525-1533.

Gazouli, M. et al. (2002) "Identification of a peptide antagonist to the peripheral-type benzodiazepine receptor that inhibits hormone-stimulated leydig cell steroid formation." J Pharmacol Exp Ther 303, 627-632.

Huang, C. et al. (2005) "Identification of peptides that bind irradiated pancreatic tumor cells." Int. J. Radiat. Oncol. Biol. Phys. 62, 1497-1503.

Kragler, F. et al. (2000) "Peptide antagonists of the plasmodesmal macromolecular trafficking pathway." EMBO J. 19, 2856-2868.

Lee, J. H., J. A. Engler, et al. (2001) "Receptor mediated uptake of peptides that bind the human transferrin receptor." Eur J Biochem 268(7): 2004-2012.

Maruta, F. et al. (2002) "Identification of FGF receptor-binding peptides for cancer gene therapy." Cancer Gene Ther 9, 543-552.

Messmer, B.T. et al. (2000) "Sequential determination of ligands binding to discrete components in heterogeneous mixtures by iterative panning and blocking (IPAB)." J. Mol. Biol. 296, 821-832.

Mortensen, H. D. (2007) "Identification of amino acids involved in the Flo11p-mediated adhesion of Saccharomyces cerevisiae to a polystyrene surface using phage display with competitive elution." J. Appl. Microbiol. 103, 1041-1047.

Rao, W.H. and R.D. Camp (2003) "Novel cyclic and linear oligopeptides that bind to integrin beta1 chain and either inhibit or costimulate T lymphocytes." Int Immunopharmacol 3, 435-443.

Shukla, G. S. and Krag, D.N. (2005) "Selection of tumor-targeting agents on freshly excised human breast tumors using a phage display library" Oncol. Rep. 13, 757-764.

White, S.J. et al. (2001) "Identification of peptides that target the endothelial cell-specific LOX-1 receptor." Hypertension 37, 449-455.

Zhao P, et al. (2007) "Identification of a Met-binding peptide from a phage display library." Clin. Canc. Res. 13, 6049-6055.

Zitzmann, S. et al (2005) "A new prostrate carcinoma binding peptide (DUP-1) for tumor imaging and therapy." Clin. Canc. Res. 11, 139-146.

top

Cell-targeting peptides

Curiel, T.J. et al. (2004) "Peptides identified through phage display direct immunogenic antigen to dendritic cells." J Immunol 172, 7425-7431.

Eidne, K.A. et al. (2000) "Selection of peptides targeting the human sperm surface using random peptide phage display identify ligands homologous to ZP3." Biol Reprod 63, 1396-1402.

Jost, P.J. et al. (2001) "A novel peptide, THALWHT, for the targeting of human airway epithelia." FEBS Lett 489, 263-269.

Kelly, K. A. et al. (2008) "Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma." PLoS Med. 5, 657-668.

Maruta, F. et al. (2003) "Use of a phage display library to identify oligopeptides binding to the lumenal surface of polarized endothelium by ex vivo perfusion of human umbilical veins." J Drug Target11, 53-59.

Mi, Z. et al. (2003) "Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium." Mol Ther 8, 295-305.

Mummert, D.I. et al. (2003) "Involvement of hyaluronan in epidermal Langerhans cell maturation and migration in vivo." J Dermatol Sci 33, 91-97.

Mummert, M.E. et al. (2000) "Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking." J Exp Med 192, 769-779.

Mummert, M.E. et al. (2002) "Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation." J Immunol 169, 4322-4331.

Mummert, M.E. et al. (2003) "Functional roles of hyaluronan in B16-F10 melanoma growth and experimental metastasis in mice." Mol Cancer Ther 2, 295-300.

Nicklin, S.A. et al. (2001) "Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells." Mol Ther 4, 174-181.

Nicklin, S.A. et al. (2001) "Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus." Mol Ther 4, 534-542.

Nicklin, S.A. et al. (2004) "In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors." J Gene Med 6, 300-308.

Nicklin, S.A. et al. (2000) "Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display." Circulation 102, 231-237.

Rasmussen, U.B. et al. (2002) "Tumor cell-targeting by phage-displayed peptides." Cancer Gene Ther 9, 606-612.

Romanczuk, H. et al. (1999) "Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choice." Hum Gene Ther 10, 2615-2626.

Samoylov, A.M. et al. (2002) "Recognition of cell-specific binding of phage display derived peptides using an acoustic wave sensor." Biomol Eng 18, 269-272.

Samoylov, A.M. et al. (2002) "Peptide biosensor for recognition of cross-species cell surface markers." J Mol Recognit 15, 197-203.

Samoylova, T.I. et al. (2002) "Targeting peptides for microglia identified via phage display." J Neuroimmunol 127, 13-21.

Samoylova, T.I. and B.F. Smith (1999) "Elucidation of muscle-binding peptides by phage display screening." Muscle Nerve 22, 460-466.

Shadidi, M. and M. Sioud (2003) "Identification of novel carrier peptides for the specific delivery of therapeutics into cancer cells." Faseb J 17, 256-258.

Shadidi, M. and M. Sioud (2004) "Selection of peptides for specific delivery of oligonucleotides into cancer cells." Methods Mol Biol 252, 569-580.

Takashima, A. et al. (2000) "New technologies to prevent and treat contact hypersensitivity responses." Ann N Y Acad Sci 919, 205-213.

Valeva, A. N. et al. (2007) "Selection and initial characterization of novel peptide ligands that bind specifically to human blood outgrowth endothelial cells." Biotechnol. Bioeng. 98, 306-312.

Work, L.M. et al. (2004) "Development of efficient viral vectors selective for vascular smooth muscle cells." Mol Ther 9, 198-208.

Zitzman, S. et al. (2007) "Identification and evaluation of a new tumor cell-binding peptide, FROP-1." J. Nucl. Med. 48, 965-972.

top

In vivo panning

Bockmann, M. et al. (2005) "Novel SRESPHP peptide mediates specific binding to primary medullary thryoid carcinoma" Hum. Gen. Ther. 16, 1267-75.

Bockmann, M. et al. (2005) "Discovery of targeting peptides for selective therapy of medullary thryroid carcinoma." J. Gene Med. 7, 179-188

Chen, Y. et al (2006) "Transdermal protein delivery by a coadministered peptide indentified via phage display." Nat. Biotech. 24, 455-460.

Denby, L et al (2007) "Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers serotype 19p." Mol. Ther. E-pub Jun 5

Duerr, D.M. et al. (2004) "Identification of peptide sequences that induce the transport of phage across the gastrointestinal mucosal barrier." J Virol Methods 116, 177-180.

Higgins, L.M. et al. (2004) "In vivo phage display to identify M cell-targeting ligands." Pharm Res 21, 695-705.

Kang, S. K. et al. (2008) "Identification of a peptide sequence that improves transport of macromolecules across intestinal mucosal barrier targeting goblet cells." J. Biotechnol. 135, 210-216.

Kelley, K. A. et al. (2006) "In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging" Mol. Imagining Biol. 8, 201-207.

Lee, L. et al. (2002) "Identification of synovium-specific homing peptides by in vivo phage display selection." Arthritis Rheum 46, 2109-2120.

Liu, C. et al. (2003) "In vivo interrogation of the molecular display of atherosclerotic lesion surfaces." Am J Pathol 163, 1859-1871.

Yao, V. J. et al (2005) "Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection " Am. J. Pathol. 166, 625-636.

top

Antimicrobial peptides

Basha, S. et al. (2006) “Polyvalent inhibitors of anthrax toxin that target host receptors.” Proc Natl Acad Sci U S A. 103, 13509-13513

da Silva, A. et al. (2002) "Avian anticoccidial activity of a novel membrane-interactive peptide selected from phage display libraries." Mol Biochem Parasitol 120, 53-60.

Dharmasena, M. N. et al. (2007) "Development of peptide mimics of a protective epitope of Vibrio cholerae Ogawa O-antigen and investigation of the structural basis of peptide mimicry." J. Biol. Chem. 282, 33805-33816.

Lavi, T. et al. (2008) "EhMLBP is an essential constituent of the Entamoeba histolytica epigenetic machinery and a potential drug target." Mol. Microbiol. 69, 55-66.

Ide, T. et al. (2003) "Identification by the phage-display technique of peptides that bind to H7 flagellin of Escherichia coli." Biosci Biotechnol Biochem 67, 1335-1341.

Knurr, J. et al. (2003) "Peptide ligands that bind selectively to spores of Bacillus subtilis and closely related species." Appl Environ Microbiol 69, 6841-6847.

Mourez, M. et al. (2001) "Designing a polyvalent inhibitor of anthrax toxin." Nat Biotechnol 19, 958-961.

Stratmann, J. et al. (2004) "A 38-kilobase pathogenicity island specific for Mycobacterium avium subsp. paratuberculosis encodes cell surface proteins expressed in the host." Infect Immun 72, 1265-1274.

Stratmann, J. et al. (2002) "Development of a Peptide-Mediated Capture PCR for Detection of Mycobacterium avium subsp. paratuberculosis in Milk." J Clin Microbiol 40, 4244-4250.

Tao, J. et al. (2000) "Drug target validation: lethal infection blocked by inducible peptide." Proc Natl Acad Sci U S A 97, 783-786.

Tinoco, L.W. et al. (2002) "NMR structure of PW2 bound to SDS micelles. A tryptophan-rich anticoccidial peptide selected from phage display libraries." J Biol Chem 277, 36351-36356.

Turnbough, C.L., Jr. (2003) "Discovery of phage display peptide ligands for species-specific detection of Bacillus spores." J Microbiol Methods 53, 263-271.

Williams, D.D. et al. (2003) "Species-specific peptide ligands for the detection of Bacillus anthracis spores." Appl Environ Microbiol 69, 6288-6293.

top

Antiviral peptides

Biorn, A.C. et al. (2004) "Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions." Biochemistry 43, 1928-1938.

Ferrer, M. and S. C. Harrison (1999) "Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries." J Virol 3, 5795-5802.

Ho, K. L. et al. (2003) "Selection of high affinity ligands to hepatitis B core antigen from a phage-displayed cyclic peptide library." J Med Virol 69, 27-32.

Ramanujam, P. et al. (2002) "Novel peptides that inhibit the propagation of Newcastle disease virus." Arch Virol 147, 981-993.

Ramanujam, P. et al. (2004) "Pathotyping of Newcastle disease virus with a filamentous bacteriophage." Biotechniques 36, 296-302.

Welch, B. D. et al. (2007) "Potent D-peptide inhibitors of HIV-1 entry." Proc Natl Acad Sci U S A. 104, 16828-33.

Yang, B. et al. (2003) "Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency Virus type I (HIV-1) Vif proteins." J Biol Chem 278, 6596-6602.

top

Anni, H. et al. (2001) "Selection of phage-display library peptides recognizing ethanol targets on proteins." Alcohol 25, 201-209.

top

Inhibitors/modulators of enzyme activity/specificity

Amin, A. et al. (2003) "Identification of constrained peptides that bind to and preferentially inhibit the activity of the hepatitis C viral RNA-dependent RNA polymerase." Virology 313, 158-169.

Chaudhary, J. et al. (2001) "Caloxin: a novel plasma membrane Ca2+ pump inhibitor." Am J Physiol Cell Physiol 280, C1027-1030.

Desjobert, C. et al. (2004) "Identification by phage display selection of a short peptide able to inhibit only the strand transfer reaction catalyzed by human immunodeficiency virus type 1 integrase." Biochem. 43, 13097-13105.

El Zoeiby, A. et al. (2003) "Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries." J Antimicrob Chemother 51, 531-543.

Giannattasio, R. B. and B. Weisblum (2000) "Modulation of erm methyltransferase activity by peptides derived from phage display." Antimicrob Agents Chemother 44, 1961-1963.

Huang, W. et al. (2003) "A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays." Protein Eng, 853-860.

Lavi, T. et al. (2008) "EhMLBP is an essential constituent of the Entamoeba histolytica epigenetic machinery and a potential drug target." Mol. Microbiol. 69, 55-66.

Li, Z. et al. (2005) "Role of molecular mimicry to HIV-1 peptides in HIV-1 related immunologic thrombocytopenia" Blood 106; 572-576.

Liu, X. (2007) "Peptides selected for the protein nanocage pores change the rate of iron recovery from the ferritin mineral." J. Biol. Chem. 282, 31821-31825.

Molinap-Lopez, J. et al. (2006) "A peptide inhibitor of MurA UDP-N-acetylglucosamine enolpyruvl transferase: the first committed step in peptidoglycan biosynthesis." Peptides 27, 3115-3121.

Paradis-Bleau, C. et al (2005) "Peptide inhibitors of the essential cell division protein FtsA." Prot. Engin, Des. & Sel. 18, 85.

Sheu, T.J. et al. (2002) "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae." J Bone Miner Res 17, 915-922.

Sticht, J. et al. (2005) "A Peptide Inhibitor of HIV-1 Assembly In Vitro." Nat. Struct. Biol. 12, 671-7.

Tao, J. et al. (2000) "Drug target validation: lethal infection blocked by inducible peptide." Proc Natl Acad Sci U S A 97, 783-786.

Yoshida, H. et al. (2003) "Improved substrate specificity of water-soluble pyrroloquinoline quinone glucose dehydrogenase by a peptide ligand." Biotechnol Lett 25, 301-305.

top

Mirror image phage display

Welch, B. D., et al. (2007) "Potent D-peptide inhibitors of HIV-1 entry." Proc Natl Acad Sci U S A. 104, 16828-33.

Wiesehan, K. et al. (2003) "Selection of D-amino-acid peptides that bind to Alzheimer’s disease amyloid peptide abeta1-42 by mirror image phage display." Chembiochem 4, 748-753.

top

Davies, J.M. et al. (1999) "Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes." Mol Immunol 36, 659-667.

Gazarian, K.G. et al. (2001) "Post-Panning Computer-Aided Analysis of Phagotope Collections Selected with Neurocysticercosis Patient Polyclonal Antibodies: Separation of Disease-Relevant and Irrelevant Peptide Sequences." Comb Chem High Throughput Screen 4, 221-235.

Makowski, L. and A. Soares (2003) "Estimating the diversity of peptide populations from limited sequence data." Bioinformatics 19, 483-489.

Rodi, D.J. et al. (2002) "Quantitative assessment of peptide sequence diversity in M13 combinatorial peptide phage display libraries." J Mol Biol 322(5): 1039-1052.

top

Construction of custom libraries in M13KE

Khalil, A.S. et. al. (2007) "Single M13 bacteriophage tethering and stretching." Proc. Natl. Acad. Sci. 104, 4892-4897.

Noren, K.A. and C.J. Noren (2001) "Construction of high-complexity combinatorial phage display peptide libraries." Methods 23, 169-178.

Oleksiewicz, M.B. et al. (2001) "Epitope mapping porcine reproductive and respiratory syndrome virus by phage display: the nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes." J Virol 75, 3277-3290.

Oleksiewicz, M.B. et al. (2002) "Porcine B-cells recognize epitopes that are conserved between the structural proteins of American- and European-type porcine reproductive and respiratory syndrome virus." J Gen Virol 83, 1407-1418.

Oleksiewicz, M.B. et al. (2004). "Phage display of the Equine arteritis virus nsp1 ZF domain and examination of its metal interactions." J Virol Methods 119, 159-169.

Sandman, K.E. et al. (2000). "Phage display of selenopeptides." J. Am. Chem. Soc. 122, 960-961.

Sandman, K.E. and C.J. Noren (2000) "The efficiency of Escherichia coli selenocysteine insertion is influenced by the immediate downstream nucleotide." Nucleic Acids Res 28, 755-761.

Sandman, K.E. et al. (2003) "Revised Escherichia coli selenocysteine insertion requirements determined by in vivo screening of combinatorial libraries of SECIS variants." Nucleic Acids Res 31, 2234-2241.

top

Material-specific peptides

Ahmad, G. et al. (2008) "Rapid bioenabled formation of ferroelectric BaTiO3 at room temperature from an aqueous salt solution at near neutral pH."J. Am. Chem. Soc. 130, 4-5.

Chen, H. et al. (2006) "QCM-D analysis of binding mechanism of phage particles displaying a constrained heptapeptide with specific affinity to SiO2 and TiO2." Anal. Chem. 78, 4872-4879.

Chen, H. et al. (2008) "Probing the interaction between peptides and metal oxides using point mutants of a TiO2-binding peptide" Langmuir 24, 6852-7.

Guo, X. and Chen, R. R. (2006) "An Improved Phage Display Procedure for Identification of Lipopolysaccharide-Binding Peptides" Biotechnol. Prog. 22, 601-4.

Matsubara, T. et al. (2003) "Selection of novel structural zinc sites from a random peptide library." FEBS Lett 555, 317-321.

Sanghvi, A. B. et al. (2005) "Biomaterials functionalization using a novel peptide that selectively binds to a conducting polymer." Nat. Mater. 4, 496-502.

Seker, U.O. et al (2007) "Adsorption behavior of linear and cyclic genetically engineered platinum binding peptides." Langmuir 23, 7895-7900.

Whaley, S.R. et al. (2000) "Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly." Nature 405, 665-668.

Wolcke, J. and E. Weinhold (2001) "A DNA-binding peptide from a phage display library." Nucleosides Nucleotides Nucleic Acids 20, 1239-1241.

Zhengding, S. et al. (2006) "Conformational selectivity of peptides for single-walled carbon nanotubes." J. Phys. Chem. B. 110, 23623-23627.

top

Small molecule-binding peptides

Janssen, G.G. et al. (2004) "Selective targeting of a laccase from Stachybotrys chartarum covalently linked to a carotenoid-binding peptide." J Pept Res 64, 10-24.

Miura, Y. et al. (2004) "Peptides binding to a Gb3 mimic selected from a phage library." Biochim Biophys Acta 1673, 131-138.

Pustowska, A. et al. (2003) "Target RNA structures derived from the HIV‑1 packaging signal psi by screening phage displayed peptide libraries." ChemBioChem 4, 1093-1097.

Qi, M. et al. (2008) "A recombinant triblock protein polymer with dispersant and binding properties for digital printing." Biopolymers 90, 28-36.

Rodi, D. J. et al. (1999) "Screening of a library of phage-displayed peptides identifies human bcl- 2 as a taxol-binding protein." J Mol Biol 285, 197-203.

Rozinov, M.N. and G.P. Nolan (1998) "Evolution of peptides that modulate the spectral qualities of bound, small-molecule fluorophores." Chem Biol 5, 713-728.

Sticht J. et al. (2005) "A peptide inhibitor of HIV-1 assembly in vitro." Nat. Struct Mol. Biol. 12, 671-7.

Zhao S.W. et al. (2005) "Selecting peptide ligands of microcystin-LR from phage displayed random libraries" Environ. Int. 31,:535-41.

top

Kundu, B. et al. (2002) "Manipulation of unfolding-induced protein aggregation by peptides selected for aggregate-binding ability through phage display library screening." Biochem Biophys Res Commun 291, 903-907.

top

Peptide mimics of non-peptide ligands

Hou, Y. and X.X. Gu (2003) "Development of peptide mimotopes of lipooligosaccharide from nontypeable Haemophilus influenzae as vaccine candidates." J Immunol 170, 4373-4379.

Jouault, T. et al. (2001) "Peptides that mimic Candida albicans-derived beta-1,2-linked mannosides." Glycobiology 11, 693-701.

top

Ehrlich, G.K. and P. Bailon (2001) "Identification of model peptides as affinity ligands for the purification of humanized monoclonal antibodies by means of phage display." J Biochem Biophys Methods 49, 443-454.

Gaskin, D.J. et al. (2001) "Phage display combinatorial libraries of short peptides: ligand selection for protein purification." Enzyme Microb Technol 28, 766-772.

Jensen, L.B. et al. (2004) "Efficient purification of unique antibodies using peptide affinity-matrix columns." J Immunol Methods 284, 45-54.

top

Baltrusch, S. et al. (2001) "Characterization of Glucokinase-binding Protein Epitopes by a Phage- displayed Peptide Library. Identification of 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase as a novel interaction partner." J Biol Chem 276, 43915-43923.

Berggard, T. et al. (2002) "myo-Inositol Monophosphatase Is an Activated Target of Calbindin D28k." J Biol Chem 277, 41954-41959.

Bitto, E. and D. B. McKay (2003) "The periplasmic molecular chaperone protein SurA binds a peptide motif that is characteristic of integral outer membrane proteins." J Biol Chem 278, 49316-49322.

BouHamdan, M. et al. (1998) "Diversity of HIV-1 Vpr interactions involves usage of the WXXF motif of host cell proteins." J Biol Chem 273, 8009-8016.

Burch, L. et al. (2004) "Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein." J Mol Biol 337, 129-45.

Burch, L.R. et al. (2004) "Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1." J Mol Biol 337, 115-128.

Chen, L. and P. B. Sigler (1999) "The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity." Cell 99, 757-768.

Dintilhac, A. and J. Bernues (2002) "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences." J Biol Chem 277, 7021-7028.

Dornan, D. et al. (2003) "The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and

allosterically controls DNA-dependent acetylation of p53." Mol Cell Biol 23, 8846-8861.

Hoff, K.G. et al. (2002) "Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU." J Biol Chem 277, 27353-27359.

Hu, B. et al. (2007) "Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. " Cancer Res. 67, 8810-8807.

Huang, J.H. et al (2007) " Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1." J. Biol. Chem. 282, 6143-6152.

Kenny, C.H. et al. (2003) "Development of a fluorescence polarization assay to screen for inhibitors of the FtsZ/ZipA interaction." Anal Biochem 323, 224-233.

MacDonald, N. J. et al. (2001) "Endostatin binds tropomyosin: A potential modulator of the anti-tumor activity of endostatin." J Biol Chem 276, 25190-25196.

Nelson, T. J. (2007) "Protection against beta-Amyloid-induced apoptosis by peptides interacting with beta-amyloid." J. Biol.Chem. 282, 31238-31249

Norgett EE et al (2007) "V 1 and V 0 domains of the human H+-ATPase are linked by an interaction between the G and a subunits." J Biol Chem. 282, 14421-14427.

Petersen, G. et al. (2001) "Dissection of the ATP binding domain of the chaperone hsc70 for interaction with the cofactor Hap46." J. Biol. Chem. 276, 10178-10184.

Sarnowski, T.J. et al. (2002) "AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf chromatin remodeling complex, interacts with FCA, a regulator of flowering time." Nucleic Acids Res 30, 3412-3421.

Sheu, T.J. et al. (2002) "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae." J Bone Miner Res 17, 915-922.

Shimizu, H., L. Burch, et al. (2002). "The conformationally-flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2-binding site whose mutation increases ubiquitination of p53 in vivo." J Biol Chem 277: 28446-28458.

Wang, X.G. et al. (2004) "Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon." J Bacteriol 186, 51-60.

top

Epitope mapping/Vaccine development

Al-Bukhari, T.A. et al. (2002) "Distinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis." Clin Exp Immunol 130, 131-139.

Al-Bukhari, T.A. et al. (2002) "An immuno-precipitation assay for determining specific interactions between antibodies and phage selected from random peptide expression libraries." J Immunol Methods 264, 163-171.

An, T. Q. et al. "Identification of a novel B cell epitope on the nucleocapsid protein of porcine reproductive and respiratory syndrome virus by phage display." Virus Genes 31, 81-87.

Ariyoshi, M. et al. (2002) "Identification of a target antigen recognized by a mouse monoclonal antibody to the bile canalicular surface of rat hepatocytes with a random phage display library." Acta Med Okayama 56, 187-191.

Birkenmeier, G. et al. (1997) "Epitope mapping by screening of phage display libraries of a monoclonal antibody directed against the receptor binding domain of human alpha2- macroglobulin." FEBS Lett 416, 193-196.

Blaydes, J.P. et al. (2001) "Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53- dependent transcription." J Biol Chem 276, 4699-4708. [phospho-speciifc antibody]

Byun, C.H. et al. (2001) "Identification of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from a phage-displayed peptide library." J Clin Endocrinol Metab 86 , 3311-3318.

Chiba, H. et al. (1999) "Introduction of mannose binding protein-type phosphatidylinositol recognition into pulmonary surfactant protein A." Biochemistry 38, 7321-7331.

Chung, J. et al. (2002) "Identification of antigenic peptide recognized by the anti-JL1 leukemia-specific monoclonal antibody from combinatorial peptide phage display libraries." J Cancer Res Clin Oncol 128, 641-649.

Danilov, S. M. et al. (2007) "Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme." Biochem. 46, 9019-9031

Davies, J.M. et al. (1999) "Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes." Mol Immunol 36, 659-667.

Dharmasena, M. N. et al. (2007) "Development of peptide mimics of a protective epitope of Vibrio cholerae Ogawa O-antigen and investigation of the structural basis of peptide mimicry." J. Biol. Chem. 282, 33805-33816.

Dore, J.M. et al. (1998) "Identification and location on syndecan-1 core protein of the epitopes of B-B2 and B-B4 monoclonal antibodies." FEBS Lett 426, 67-70.

Eshaghi, M. et al. (2006) "Idenitification of epitopes in the nucleopcapsid protein nipah virus using a linear phage-displayed random peptide library." Mol. Immunol. 43, 268-278.

Ferrer, M. et al. (1999) "Structural and functional characterization of an epitope in the conserved C-terminal region of HIV-1 gp120." J Pept Res 54, 32-42.

Gazarian, K.G. et al. (2000) "Epitope mapping on N-terminal region of taenia solium paramyosin." Immunol Lett 72, 191-195.

Gazarian, T. et al. (2000) "Isolation and structure-functional characterization of phage display library-derived mimotopes of noxiustoxin, a neurotoxin of the scorpion Centruroides noxius Hoffmann." Mol Immunol 37, 755-766.

Gazarian, T.G. et al. (2003) "Potential of peptides selected from random phage-displayed libraries to mimic conformational epitopes: a study on scorpion toxin Cn2 and the neutralizing monoclonal antibody BCF2." Comb Chem High Throughput Screen 6, 119-132.

Gevorkian, G. et al. (1998) "Identification of autoimmune thrombocytopenic purpura-related epitopes using phage-display peptide library." Clin Immunol Immunopathol 86, 305-309.

Gevorkian, G. et al. (2000). "Identification of mimotopes of platelet autoantigens associated with autoimmune thrombocytopenic purpura." J Autoimmun 15, 33-40.

Gu, H. W. et al. (2006) "Selection of immunodominant mimics of IROMP-99 of rabbit Pasteurella multocida from a random 12-peptide library." Vet. Microbiol. Mar 31 e-pub

Gu, Y. et al. (2004) "Selection of a peptide mimicking neutralization epitope of hepatitis E virus with phage peptide display technology." World J Gastroenterol 10, 1583-1588.

Han, Z.Y. et al. (2003) "Screening and identification of mimotope of gastric cancer associated antigen MGb1-Ag." World J Gastroenterol 9, 1920-1924.

Hessian, P.A. and L. Fisher (2001) "The heterodimeric complex of MRP-8 (S100A8) and MRP-14 (S100A9). Antibody recognition, epitope definition and the implications for structure." Eur J Biochem 268, 353-363.

Hollborn, M. et al. (1999) "Epitope mapping of a monoclonal antibody directed against the alpha-subunit of phosphofructokinase-1 from Saccharomyces cerevisiae by screening phage display libraries." J Mol Recognit 12, 33-37.

Hu, S. et al. (2007) "Epitope mapping and structural analysis of an anti-ErbB2 antibody A21: Molecular basis for tumor inhibitory mechanism" Proteins 70, 938-949.

Ikuno, N. et al. (2001) "A comparative study of antibody expressions in primary biliary cirrhosis and autoimmune cholangitis using phage display." Hepatology 34, 478-486.

Itoh, K. et al (2007) "Identification of cell proliferation-associated epitope on CD98 oncoprotein using phage display random peptide library." Cancer Sci 98, 1696-1700.

Jensen, L.B. et al. (2004) "Efficient purification of unique antibodies using peptide affinity-matrix columns." J Immunol Methods 284, 45-54.

Junjian X. et al. (2005) "Screening of the antigen epitopes of basic fibroblast growth factor by phage display." J. Biochem. Mol. Biol. 38, 290-293.

Li, Y. et al. (2007) "Production of mouse monoclonal antibodies against Helicobacter pylori Lpp20 and mapping the antigenic epitope by phage display library." J. Immunol. Methods 325, 1-8.

Manivel, V. et al. (2002) "The primary antibody repertoire represents a linked network of degenerate antigen specificities." J Immunol 169, 888-897.

Manoutcharian, K. et al. (1999) "Characterization of cerebrospinal fluid antibody specificities in neurocysticercosis using phage display peptide library." Clin Immunol 91, 117-121.

Messmer, B.T. et al. (1999) "Two human neonatal IgM antibodies encoded by different variable-region genes bind the same linear peptide: evidence for a stereotyped repertoire of epitope recognition." J Immunol 162, 2184-2192.

Mohammadi, M. et al (2007) "Epitope mapping of PR81 anti-MUC1 monoclonal antibody following pepscan and phage display techniques." Hybridoma 26, 2007.

Na, C.H. et al. (2003) "A method for identification of the peptides that bind to a clone of thyroid-stimulating antibodies in the serum of Graves’ disease patients." J Clin Endocrinol Metab 88, 1570-1576.

Naz, R. K. (2005) "Search for peptide sequences involved in human antisperm antibody-mediated male immunoinfertility by using phage display technology." Mol. Reprod. Dev.72,:25-30.

Naz, R. K. (2005) "Antisperm vaccine for contraception." Am. J. Reprod. Immunol. 54, 378-383.

O'Nuallain, B. et al (2007) "Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope." Biochem. 46, 13049-13058.

Osman, A.A. et al. (1998) "Use of the phage display technique for detection of epitopes recognized by polyclonal rabbit gliadin antibodies." FEBS Lett 433, 103-107.

Osman, A.A. et al. (2000) "B cell epitopes of gliadin." Clin Exp Immunol 121, 248-254.

Osman, A.A. et al. (2001) "A monoclonal antibody that recognizes a potential coeliac-toxic repetitive pentapeptide epitope in gliadins." Eur J Gastroenterol Hepatol 13, 1189-1193.

Ostrowski, M. et al. (2002) "Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain." J Virol 76, 4241-4250.

Ostrowski, M. et al. (2003) "B-cell epitopes in the immunodominant p34 antigen of mycobacterium avium ssp. paratuberculosis recognized by antibodies from infected cattle." Scand J Immunol 58, 511-521.

Ouyang, L. et al. (2003) "Partial protection induced by phage library-selected peptides mimicking epitopes of Schistosoma japonicum." Chin Med J (Engl) 116, 138-141.

Palacios-Rodriguez, Y. et al (2007) "Collection of phage-peptide probes for HIV-1 immunodominant loop-epitope." J. Microbiol. Methods 68, 225-235.

Payne, A. S. et al. (2007) "Targeting pemphigus autoantibodies through their heavy-chain variable regions." J. Investigative Dermatology 127, 1681-91.

Perosa, F. et al (2006) "Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid spingomyelinase-like phosphodiesterase 3b precursor." Blood 107, 1070-1077.

Perosa, F. et al. (2003) "Beta 2-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide." J Immunol 171, 1918-1926.

Petit, M.A. et al. (2003) "Mapping of a conformational epitope shared between E1 and E2 on the serum-derived human hepatitis C virus envelope." J Biol Chem 278, 44385-44392.

Qiu, J. X. and D. M. Marcus (1999) "Use of peptide ligands to analyze the fine specificity of antibodies against asialo GM1." J Neuroimmunol 100, 58-63.

Rowley, M.J. et al. (2000) "Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display." J Immunol 164, 3413-3419.

Santamaria, H. et al. (2001) "Identification of peptide sequences specific for serum antibodies from human papillomavirus-infected patients using phage display libraries." Clin Immunol 101, 296-302.

Sanz, L. et al. (2003) "A novel cell binding site in the coiled-coil domain of laminin involved in capillary morphogenesis." Embo J 22, 1508-1517.

Spillner, E. et al. (2003) "Paratope-based protein identification by antibody and peptide phage display." Anal Biochem 321, 96-104.

Su, Y. et al. (2003) "The a -subunit of the V-type H+-ATPase interacts with phosphofructokinase-1 in humans." J Biol Chem 278, 20013-20018.

Tang, L.F. et al. (2004) "Schistosoma japonicum: Isolation and Identification of Peptides Mimicking Ferritin Epitopes from Phage Display Library." Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 36, 206-210.

Tang, S.S. et al. (2003) "Mimotopes of the Vi antigen of Salmonella enterica serovar typhi identified from phage display peptide library." Clin Diagn Lab Immunol 10, 1078-1084.

Tarr, W. A. et al. (2006) "Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33." Hepatology 43, 592-601.

von Landenberg, P. et al. (1999) "A new antigenic epitope localized within human kappa light chains specific for rheumatoid arthritis and systemic lupus erythematosus." J Autoimmun 13, 83-87.

Wang, C. J. et al. (2004) [Screening and identification of mimic epitopes of monoclonal antibodies against hantaan virus using phage display technique] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20, 429-432.

Wu, H.C. et al. (2001) "Identification of B-cell epitope of dengue virus type 1 and its application in diagnosis of patients." J Clin Microbiol 39, 977-982.

Wu, H.C. et al. (2003) "Identification of a dengue virus type 2 (DEN-2) serotype-specific B-cell epitope and detection of DEN-2-immunized animal serum samples using an epitope-based peptide antigen." J Gen Virol 84, 2771-2779.

Wu, H.C. et al. (2001) "Characterization of Neutralizing Antibodies and Identification of Neutralizing Epitope Mimics on the Clostridium botulinum Neurotoxin Type A." Appl Environ Microbiol 67, 3201-3207.

Yang, W. J. et al (2005) " Epitope mapping of mycoplasma hyopneumoniae using phage displayed peptide libraries and the immune responses of the selected phagotypes." J. Immunol. Methods 304, 15-29.

Youn, J.H. et al. (2004) "Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae." FEMS Immunol Med Microbiol 41, 51-57.

Zhang, F. et al (2006) " Characterization of epitopes for neutralizing monoclonal antibodies to classical swine fever virus E2 and E(rns) using phage-displayed random peptide library." Arch. Virol. 151, 37-54.

top

Updated March 13, 2007.