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Home >  Technical Reference > Epigenetics > Overview Overview  Epigenetics   Overview What is Epigenetics? DNA and Histone Modifications Studying DNA Methylation      EpiMark DNA Enrichment EpiMark Bisulfite Conversion EpiMark 5-mC and 5-hmC Analysis Restriction Enzymes for Epigenetics   Histones and EpiMark Nucleosome Assembly Methyltransferases for Epigenetics Control DNA ChIP   For over 35 years, New England Biolabs, Inc. has been committed to understanding the mechanisms of restriction and methylation of DNA. This expertise in enzymology has recently led to the development of a suite of new reagents validated in epigenetic applications. EpiMark® validated reagents simplify epigenetics research and expand the potential for biomarker discovery. This growing line of reagents and kits includes: The EpiMark® Methylated DNA Enrichment Kit to enrich double-stranded methyl-Cpg from fragmented genomic DNA with as little as 5 ng of input DNA The EpiMark® Bisulfite Conversion Kit to detect methylated cytosine via the conversion of unmodified cytosines to uracil EpiMark® Hot Start Taq DNA Polymerase to amplify bisulfite-treated samples The EpiMark® 5-mC and 5-hmC Analysis Kit for locus-specific identification and quantification of 5-hydroxymethylcytosine A novel family of methylation-dependent restriction endonucleases, and enzymes with differential sensitivity to methylation, useful for mapping epigenetic modifications Highly purified, recombinant histones for substrates in purification and characterization of histone modification enzymes DNA methyltransferases to generate methylated DNA at specific sites for gene expression studies Protein methyltransferases for specific histone modification required by gene regulation studies Modified and unmodified genomic DNAs to use as controls For more information, download our Epigenetics Technical Guide, or click here to have one sent to you.   Epigenetic Online Resources • E3: Engaging Epigenetic Experts online scientific community • Interactive Tutorial explaining the phenomenon of epigenetics at a molecular level