FAQ: Can I use α2-3,6,8,9 Neuraminidase A in a double digest with Endo H/Hf, O-Glycosidase or PNGase F?

Yes. α2-3,6,8,9 Neuraminidase A has activity over a broad pH range, and has been found to work well on a protein that has been denatured. Neuraminidase shows normal activity even in the presence of 1% BME, and 0.5% SDS.